生物
酰化
胰岛素
磷酸化
胰岛素受体
转运蛋白
相扑蛋白
细胞生物学
生物化学
泛素
胰岛素抵抗
内分泌学
基因
催化作用
作者
Luke H. Chamberlain,Michael J. Shipston,Gwyn W. Gould
出处
期刊:Open Biology
[The Royal Society]
日期:2021-03-01
卷期号:11 (3)
被引量:9
摘要
Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function. By contrast, protein S-acylation, although a widespread PTM with important functions in most physiological systems, has received far less attention. Perturbations in S-acylation are linked to various disorders, including intellectual disability, cancer and diabetes, suggesting that this less-studied modification is likely to be of considerable biological importance. As an exemplar, in this review, we focus on the newly emerging links between S-acylation and the hormone insulin. Specifically, we examine how S-acylation regulates key components of the insulin secretion and insulin response pathways. The proteins discussed highlight the diverse array of proteins that are modified by S-acylation, including channels, transporters, receptors and trafficking proteins and also illustrate the diverse effects that S-acylation has on these proteins, from membrane binding and micro-localization to regulation of protein sorting and protein interactions.
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