Cancer Immunotherapy: Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy (Adv. Mater. 12/2021)

In article number 2006003, Yuan Ping and co-workers, by means of photothermal transcription of CRISPR/Cas9 in the second near-infrared window, demonstrate genome editing of PD-L1 to be effective to reprogram the tumor microenvironment. The photothermal genome editing for the disruption of PD-L1 mediated by supramolecular gold nanorods also simultaneously activates T cells to infiltrate and attack tumor cells in the deep tissues, which can substantially improve cancer immunotherapy.