细胞生物学
巨噬细胞极化
微泡
牙髓干细胞
MAPK/ERK通路
化学
活性氧
干细胞
巨噬细胞
牙周膜干细胞
信号转导
NF-κB
癌症研究
生物
小RNA
生物化学
碱性磷酸酶
酶
体外
基因
作者
Chao Liu,Fanqi Hu,Genlong Jiao,Yue Guo,Pan Zhou,Yuning Zhang,Zhen Zhang,Jing Yi,Yong You,Zhizhong Li,Hua Wang,Xuesong Zhang
标识
DOI:10.1186/s12951-022-01273-4
摘要
Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, the roles of ROS and exosomes in the process of M1 macrophage polarization are not known. Herein, we demonstrated that ROS can induce M1 macrophage polarization and have a concentration-dependent effect. ROS can induce M1 macrophage polarization through the MAPK-NFκB P65 signaling pathway. Dental pulp stem cell (DPSC)-derived exosomes can reduce macrophage M1 polarization through the ROS-MAPK-NFκB P65 signaling pathway in treating SCI. This study suggested that DPSC-derived exosomes might be a potential drug for treating SCI. Disruption of the cycle between ROS and M1 macrophage polarization might also be a potential effective treatment by reducing secondary damage.
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