硼酸化
铱
区域选择性
化学
催化作用
吡啶
位阻效应
组合化学
有机化学
烷氧基
药物化学
芳基
烷基
作者
Hafiza Tayyaba Shahzadi,Saman Fatima,Naseem Akhter,Meshari Alazmi,Alshammari Nawaf,Kamaleldin B. Said,Amer AlGhadhban,Abdel Moneim Elhadi Sulieman,Rahman Shah Zaib Saleem,Ghayoor Abbas Chotana
标识
DOI:10.1021/acsomega.2c00773
摘要
Iridium-catalyzed C-H borylation of CF3-substituted pyridines is described in this paper. The boronic ester group can be installed on the α, β, or γ position of pyridine by an appropriate substitution pattern. Sterically governed regioselectivity provides convenient access to a variety of CF3-substituted pyridylboronic esters. These catalytic C-H borylation reactions were carried out neatly without the use of any solvent. Several functional groups, such as halo, ester, alkoxy, amino, etc., are compatible with this methodology. These pyridylboronic esters are amenable to column chromatography and the products were isolated in good to excellent yields. α-Borylated pyridines, although isolated in good yields, do not have a long shelf life. The boronic ester derivatives of these CF3-substituted pyridines can serve as useful precursors in the synthesis regime.
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