生物
细胞生物学
活体显微镜检查
炎症
周细胞
中性粒细胞胞外陷阱
免疫学
体内
内皮干细胞
体外
生物化学
生物技术
作者
Stefan Uderhardt,Andrew J. Martins,John S. Tsang,Tim Lämmermann,Ronald N. Germain
出处
期刊:Cell
[Elsevier]
日期:2019-04-01
卷期号:177 (3): 541-555.e17
被引量:255
标识
DOI:10.1016/j.cell.2019.02.028
摘要
Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an inescapable consequence of parenchymal cell death has not been explored. Using a combination of dynamic intravital imaging and confocal multiplex microscopy, we report here that tissue-resident macrophages rapidly sense the death of individual cells and extend membrane processes that sequester the damage, a process that prevents initiation of the feedforward chemoattractant signaling cascade that results in neutrophil swarms. Through this “cloaking” mechanism, the resident macrophages prevent neutrophil-mediated inflammatory damage, maintaining tissue homeostasis in the face of local cell injury that occurs on a regular basis in many organs because of mechanical and other stresses.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiIwNTY4MWE4NGVhOWYyMGU3NGQyNGJiNDEwYzU5YzI5NSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4OTQ4MTQ2fQ.RgoGSvtSXDmPQ85kYGsAEMOtnzIwntpyqSv0K5WPum-F3nG54HU2D5QK22j0c3kGC17LmyRLR7UizzQ_H0U_VWZ0WS_dUlmWRrXUm_g1coUzWZRcEw9xrdkdWQBh5n84scoaavsE0TDBPO1DPzNy_gsChUBfVs8sKCNhZO3TldAh5iopzZrQE-mvBh56o64_aqCdVjJjP89bwYaEem97Y0Hjc4rV3RlwWblBo5V5Jpbl7ir0SHIjRj-q3J3021T9ParyvD4XHzlY-hl-5JmFEzx_RxjmoI1HOZxZP3sPrG1pyZwh0OrHc9vtLMZirjwbYo2WFZBQlPbwJucUr8Rtvw(mp4, (43.26 MB) Download video
科研通智能强力驱动
Strongly Powered by AbleSci AI