化学
外消旋化
化学选择性
组合化学
肽合成
碘
肽
差向异构体
试剂
氨基酸
有机化学
催化作用
生物化学
作者
Wanjin Zhong,Chuan Wan,Ziyuan Zhou,Chuan Dai,Yichi Zhang,Fei Lu,Feng Yin,Zigang Li
标识
DOI:10.1021/acs.orglett.3c03539
摘要
Through systematic optimization of halopyridinium compounds, we established a peptide coupling protocol utilizing 4-iodine N-methylpyridinium (4IMP) for solid-phase peptide synthesis (SPPS). The 4IMP coupling reagent is easily prepared, bench stable, and cost-effective. Employing 4IMP in the SPPS process has showcased remarkable chemoselectivity and efficiency, effectively eliminating racemization and epimerization. This achievement has been substantiated through the successful synthesis of a range of peptides via the direct utilization of commercially available amino acid substrates for SPPS.
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