化学
行动方式
计算生物学
小分子
纳米技术
组合化学
生物
生物化学
材料科学
作者
David Darwish,Hany A.M. El-Sherief,Salah A. Abdel‐Aziz,Gamal El‐Din A. Abuo‐Rahma
标识
DOI:10.1002/ardp.202300758
摘要
Over the past decades, cancer has been a challenging domain for medicinal chemists as it is an international health concern. In association, small molecules such as 2-aminothiophenes and their derivatives showed significant antitumor activity through variable modes of action. Therefore, this article aims to review the advances regarding these core scaffolds over the past 10 years, where 2-aminothiophenes and their fused analogs are classified and discussed according to their biological activity and mode of action, in the interest of boosting new design pathways for medicinal chemists to develop targeted antitumor candidates.
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