Application and Research Status of <sup>125</sup>I Seeds Brachytherapy in Unresectable Pancreatic Cancer

Pancreatic cancer is a digestive system tumor with high degree of malignancy. At present, systemic chemotherapy is the main treatment method. However, due to the difficulty in early diagnosis and easy spread of pancreatic cancer, the survival cycle of patients is short and the treatment effect is poor. ¹²⁵I seed brachytherapy has obvious advantages in the treatment of malignant tumors, and has been widely used in the treatment of unresectable pancreatic cancer. Either used alone or combined with chemotherapy, the treatment of ¹²⁵I seed brachytherapy can effectively relieve pain, improve life quality and prolong survival. However, there are few reports about the application status. This article reviews the current updates of ¹²⁵I seed brachytherapy for resectable pancreatic cancer, and expounds the application status of ¹²⁵I seeds brachytherapy in combination with monotherapy chemotherapy, dual drug chemotherapy, targeted therapy, immunity therapy, palliative surgery, external radiotherapy and traditional Chinese medicine. Based on the retrospective review, future directions of research and development of brachytherapy for unresectable pancreatic cancer is also proposed, to provide better treatment care for pancreatic cancer patients. At present, there are still many problems to be solved, such as formulating the principles and standards for the application of radioactive particle implantation in the comprehensive treatment of pancreatic cancer; We will continue to standardize and optimize the operation process and distribution means of radioactive seed implantation technology, and better promote 125I radioactive seed implantation technology.