Comparison of 18F-FDOPA and 18F-MFBG PET/CT Images of Metastatic Pheochromocytoma

A 30-year-old man with pheochromocytoma was hospitalized for hemoptysis without inducement. CT revealed a mass in the left lung, and biopsy pathology under the bronchoscope suggested that it was a pheochromocytoma metastasis. To further identify the location of the metastatic lesions, the patient was enrolled in a clinical trial and underwent 18F-FDOPA and 18F-MFBG PET/CT. Images from both examinations showed similar lesions. However, the lesions differed in that the uptake of some lesions was significantly higher with 18F-FDOPA than with 18F-MFBG, whereas the para-aortic lesion was active in 18F-MFBG but not in 18F-FDOPA.