The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart Disease

The CMR phenotype of LMNA carriers with preserved left ventricular systolic function consists of longer T₂, higher serum troponin levels, higher extracellular volume, and impaired strain. CMR-derived focal fibrosis and strain biomarkers are prognostic, and future studies should explore their added clinical utility beyond the currently available MACE risk prediction tools. (The Deep Phenotype of Lamin A/C Cardiomyopathy; NCT03860454).