自愈水凝胶
聚丙烯酰胺
材料科学
粘附
甲基丙烯酰胺
丙烯酰胺
纳米凝胶
胶粘剂
复合材料
低临界溶液温度
表面改性
肿胀 的
化学工程
高分子化学
聚合物
纳米技术
共聚物
药物输送
图层(电子)
工程类
作者
Tao Wang,Weijie Zhao,Yue Wu,Xiaohan Wang,A. Basak Kayitmazer,Ayyaz Ahmad,Naveed Ramzan,Yi Si,Jie Wang,Yisheng Xu
标识
DOI:10.1021/acsapm.2c01649
摘要
The adhesion and mechanical properties of hydrogels used for vascular wound repair often deteriorate dramatically on wet surfaces, resulting in ineffective repair. In this work, a poly(N-isopropyl acrylamide-co-dopamine methacrylamide) nanogel with dopamine groups was synthesized and introduced into a polyacrylamide (PAAm) hydrogel to produce temperature-responsive hydrogels, which greatly improved mechanical and adhesive properties of PAAm hydrogels. Nanogel-reinforced PAAm (NR-PAAm hydrogel) can adhere to the surface of various solid materials and biological tissues through special physical interactions, which exhibited different mechanical and adhesion properties as temperature changes below or above the lower critical solution temperature (LCST). The maximum adhesion of the NR-PAAm hydrogel on the aluminum surface was 78 kPa. In addition, the NR-PAAm hydrogel exhibited sufficient mechanical properties with a fracture stress of 103.6 kPa at a fracture strain of 1800%. The NR-PAAm hydrogel has good adhesion on wet surfaces and could adhere for 600 s at a pressure difference of 30 mmHg. Hence, the obtained temperature-responsive hydrogels have excellent tunable mechanical properties and adhesion properties, which provides a theoretical basis for the development of vascular repair materials in the future.
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