Patient-Reported Paresthesia After Administration of Suzetrigine: A Case Report

Suzetrigine is a novel non-opioid analgesic for treating moderate to severe acute pain. Clinical trials for postoperative pain demonstrated that the most common side effects were headache and constipation. Since it became commercially available in March of 2025, there have been no case reports of unanticipated problems. However, the wider use of this first-in-class drug outside of clinical trials may lead to reports of additional side effects, interactions, or intolerances. We present the case of a patient experiencing paresthesia following administration of suzetrigine for refractory postoperative pain.