Advanced bioactive materials and strategies for tendon repair and function restoration

This review synthesizes tendon regeneration strategies-from molecular mechanisms to tissue-level integration-including bioactive component selection and delivery systems using tissue-engineered scaffolds. It identifies translational barriers and proposes new strategies in tendon-specific safety validation, scalable manufacturing uniformity and cost-effectiveness versus conventional therapies. These insights will refine clinical strategies for tendon injuries and advance targeted bioactive biomaterials for localized regeneration.