化学
炔丙基
炔烃
催化作用
串联
羰基化
卡宾
电泳剂
级联反应
反应性(心理学)
组合化学
级联
废止
分子
有机化学
一氧化碳
医学
材料科学
替代医学
病理
色谱法
复合材料
作者
Guojing Zhu,Xuefeng Jiang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-07
卷期号:25 (45): 8077-8082
被引量:2
标识
DOI:10.1021/acs.orglett.3c03132
摘要
A Rh(I)-catalyzed carbene migration/carbonylation/cyclization (MCC) strategy has been established for the construction of diverse functionalized carbazoles from propargyl α-diazoindolacetates. Rh(I)-stabilized carbene with different electrophilic properties displays specific reactivity toward alkyne and CO during the transformation, ensuring the smooth progress of the tandem cyclization. Other heteroaryl scaffolds were achieved simultaneously through this cascade protocol, thus offering a straightforward pathway toward functionalized polycyclic aromatic molecule synthesis.
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