壳聚糖
伤口愈合
银纳米粒子
化学
纳米颗粒
伤口敷料
纳米技术
材料科学
外科
医学
复合材料
有机化学
作者
Roxane Abdel-Gawad,Rihab Osman,Gehanne A.S. Awad,Nahed D. Mortada
标识
DOI:10.1016/j.carbpol.2023.121526
摘要
Interactive wound dressings combining healing and antimicrobial potentials, besides ensuring patient compliance with a recognized wound care service gained considerable interest recently. Both hydrogel spray dried microparticles (HMP) and soft hydrogel (G) were prepared. The bio-inspired combinatory platform included natural bio-macromolecules namely: chitosan (CS) and collagen (COL) with wound healing enhancement and connective tissue building capabilities cross linked with the natural genipin (GN) to build a three dimensional structured matrix. The optimized plain hydrogel obtained by a box behnken design (BBD) program (G) scored maximum swelling and porosity. The network was hosted with green synthesized cefotaxime sodium (cef.Na) AgNPs reduced by the anabolic folic acid (FA). Both hydrogels exhibited good antimicrobial activity against gram +ve and -ve bacteria. The wound healing activity, evaluated in injured rats, showed >98 % and complete wound closure after two and three weeks respectively. Oxidative stress minimization was proved by the estimation of biochemical markers malondialdehyde (MDA) and superoxide dismutase (SOD) levels at the wound site.
科研通智能强力驱动
Strongly Powered by AbleSci AI