Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives

In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate. We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer cells and MTT test for measurement of viable cell numbers were also performed. Keywords: Functionalization, carboxylated multiwall carbon nanotubes, amantadine, pregabalin and alendronate.