医学
二甲双胍
顺从(心理学)
糖尿病
2型糖尿病
药品
格列本脲
重症监护医学
2型糖尿病
内科学
药理学
内分泌学
心理学
社会心理学
出处
期刊:PubMed
日期:2003-04-01
卷期号:29 (2 Pt 3): S31-7
被引量:5
摘要
Compliance is an old issue but crucial in the management of chronic diseases. This is the case in type 2 diabetes mellitus which requires several drugs, either to treat diabetes or to prevent cardiovascular complications. In this review, we discuss the relationships between drug treatment regimens and treatment compliance in type 2 diabetes and other chronic diseases. The greater the number of daily drug intakes, the worst the compliance, even if a single daily intake may cause an increased risk of overdosing. Although the number of tablets or treatments is less frequently linked to compliance level than the number of daily intake, polytherapy is generally associated with a poor compliance. The consequences of a poor compliance on the prognosis or the management of these diseases are analysed based on cardiovascular studies. Even if nearly no studies exist in type 2 diabetes, to improve treatment compliance represents a major challenge in these patients. Such improvement requires to preferentially use once-a-day intake, but this is still difficult with several oral anti-diabetics. Fixed combinations such as the glibenclamide plus metformin combination, cause a decrease in the number of daily tablets and this permit a better compliance. Such approaches, to be fully beneficial, should be part of a global management of these type 2 diabetic patients, taking into account all their difficulties to follow their treatments, and based on a strong physician and patient relationship.
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