Hypotensive Resuscitation of Rats with Uncontrolled Hemorrhagic Shock

Objective To establish a rat hypotensive and uncontrolled hemorrhagic shock model, and to compare the difference between normal MAP resuscitation and hypotensive resuscitation groups. Methods Following the model established,fourty Wistar rats were randomly and equally divided into four groups:Group 1,sham-operation group;group 2,untreated shock group;group 3,normal MAP resuscitation group (during acute resuscitation phase MAP was kept at 80 mmHg),and group 4,hypotensive resuscitation group (during acute resuscitation phase MAP was kept at 60±5 mmHg). To observe and analyze the survival rate and the degree of organ injuries. Results The survival time of rats in the hypotensive resuscitation group was significantly longer than that of the normal MAP resuscitation group. Conclusions In comparison with normal blood pressure resuscitation,hypotensive resuscitation can improve tissue metabolism and prolong survival time during resuscitation from uncontrolled hemorrhagic shock. Hypotensive resuscitation is a more reliable resuscitation method in comparison with normal blood pressure resuscitation.