生物
小RNA
形态发生
细胞生物学
信使核糖核酸
劈理(地质)
遗传学
核糖核酸
RNA干扰
拟南芥
基因
突变体
断裂(地质)
古生物学
作者
Javier F. Palatnik,Edwards Allen,Xuelin Wu,Carla Schommer,Rebecca Schwab,James C. Carrington,Detlef Weigel
出处
期刊:Nature
[Springer Nature]
日期:2003-08-20
卷期号:425 (6955): 257-263
被引量:1612
摘要
Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.
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