Versatile Oligo( N ‐Substituted) Glycines: The Many Roles of Peptoids in Drug Discovery

Introduction Peptoid Synthesis Solid-Phase Synthesis Sub-monomer Solid-Phase Method Side Reactions Post-Synthetic Analysis Drug Discovery via Small-Molecule Peptoid Libraries Peptoid Drugs from Combinatorial Libraries Peptoid Inhibitors of RNA-Protein Interactions Peptoid-Based Drug Delivery and Molecular Transporters: Cellular Uptake Peptoid Mimics of HIV-Tat Protein Cellular Delivery of Nucleic Acids Peptoid Mimics of Peptide Ligands Peptoids with Folded Structure Restricting Conformational Space Peptoid Helices CD and NMR Studies of a Helical Peptoid Pentamer with α-Chiral Aromatic Side Chains CD Studies of Longer Peptoid Helices Containing α-Chiral Aromatic Side Chains Structural Studies of Peptoids with Aliphatic Side Chains by CD, NMR, and X-ray Crystallography Summary Protein-mimetic Structures Biomimetic Peptoid Structures for Therapeutic Applications Peptoid Mimics of Antibacterial Peptides Peptoid-Based Mimics of Lung Surfactant Proteins Collagen-based Structures Containing Peptoid Residues Obstacles to the Development of Biomedically-useful Peptoids Enhance the Diversity of Secondary Structure in Peptoid Foldamers Improve Understanding of Peptoid Sequence/Structure Relationships Translate Bioactive Peptide Sequences into Bioactive Peptoid Sequences Develop Peptoids with Stable Tertiary Structure Develop Peptoid Shuttles for Intracellular Import of Xenobiotic Agents Optimize Pharmacological Profile of Oligopeptoids Conclusion References