蜕膜
生物
免疫学
细胞生物学
钥匙(锁)
接口(物质)
胎儿
胎盘
怀孕
生态学
遗传学
吉布斯等温线
生物化学
肺表面活性物质
作者
Jacob Hanna,Debra Goldman‐Wohl,Yaron Hamani,Inbal Avraham,Caryn Greenfield,Shira Natanson-Yaron,Diana Prus,Leonor Cohen-Daniel,Tal I. Arnon,Irit Manaster,Roi Gazit,Vladimir Yutkin,Daniel Benharroch,Angel Porgador,Eli Keshet,Simcha Yagel,Ofer Mandelboim
出处
期刊:Nature Medicine
[Springer Nature]
日期:2006-08-06
卷期号:12 (9): 1065-1074
被引量:1466
摘要
Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood-derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein-10 chemokines. Furthermore, dNK cells are potent secretors of an array of angiogenic factors and induce vascular growth in the decidua. Notably, such functions are regulated by specific interactions between dNK-activating and dNK-inhibitory receptors and their ligands, uniquely expressed at the fetal-maternal interface. The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development.
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