Construction of Gelatin Microsphere / Magnesium Phosphate Bone Cement Composite Drug Sustained Delivery System

Emulsification crosslinking method was applied to prepare drug-loaded gelatin microspheres, of which the particle size was mainly between 100-300 μm.The influence of the crosslinking agent content, drug content and rotation speed on the drug-loading rate and encapsulation efficiency and the influence of the drug content and rotation speed on the microspheres' diameter were analyzed.The drug-loaded gelatin microspheres were deliberately combined with magnesium phosphate cement to produce porous magnesium phosphate composite bone cement with drug slow-release property, and then the changes of porosity of the composite system in the process of microsphere degradation and the drug release characteristics of the composite system in vitro were both explored.Results show that with the increase of glucose concentration, both the drug-loading rate and encapsulation efficiency increase firstly and then decrease, while both the drug content and the drug-loading rate increase and the encapsulation efficiency increases firstly and then decreases.Both the drug-loading rate and encapsulation efficiency decrease with the increase of rota-