生物发生
核糖体
功能(生物学)
细胞生物学
核糖核酸
化学
DNA
核酸
生物
信号转导
生物物理学
生物化学
基因
作者
Salman F. Banani,Hyun O. Lee,Anthony Hyman,Michael K. Rosen
摘要
Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack surrounding membranes but function to concentrate proteins and nucleic acids. These condensates are involved in diverse processes, including RNA metabolism, ribosome biogenesis, the DNA damage response and signal transduction. Recent studies have shown that liquid-liquid phase separation driven by multivalent macromolecular interactions is an important organizing principle for biomolecular condensates. With this physical framework, it is now possible to explain how the assembly, composition, physical properties and biochemical and cellular functions of these important structures are regulated.
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