荧光
谷胱甘肽
纳米颗粒
生物传感器
纳米技术
氧化还原
材料科学
选择性
组合化学
化学
生物物理学
无机化学
生物化学
催化作用
量子力学
生物
物理
酶
作者
Xiang‐Juan Kong,Shuang Wu,Tingting Chen,Ru‐Qin Yu,Xia Chu
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2016-01-01
卷期号:8 (34): 15604-15610
被引量:87
摘要
Polydopamine (PDA) nanoparticles, as a kind of popular polymer material, have attracted a great deal of attention from various areas including materials science, biomedicine, energy, environmental science and so on owing to their striking physicochemical properties. Herein, we reported for the first time the synthesis of intrinsic fluorescent PDA nanoparticles using MnO2 as an oxidant. In the presence of MnO2, dopamine was quickly oxidized into its quinone derivative, and autopolymerized into fluorescent PDA nanoparticles. Using fluorescent PDA nanoparticles as a fluorescence signal indicator, we further established a cost-effective sensor for rapid, sensitive and selective sensing of reduced glutathione (GSH) based on the redox reaction between MnO2 and GSH, and the key role of MnO2 in the formation of fluorescent PDA nanoparticles. GSH has the capability of reducing MnO2 into Mn2+, which inhibited the formation of the fluorescent PDA nanoparticles. Thus, the concentration of GSH was directly related to the decreased fluorescence signal intensity of the PDA nanoparticles. The sensor showed good sensing performance for GSH detection with high sensitivity and desirable selectivity over other potential interfering species. Additionally, the sensor exhibited excellent practical applications for GSH detection in human whole blood samples, which presents potential applications in biological detection and clinical diagnosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI