胎儿
髓腔
生物
前体细胞
胸腺细胞
男科
细胞
细胞生物学
免疫学
细胞生长
内科学
内分泌学
细胞分裂
细胞培养
T细胞
解剖
免疫系统
医学
怀孕
生物化学
遗传学
作者
Francine Jotereau,F Heuze,V Salomon-Vie,H Gascan
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1987-02-15
卷期号:138 (4): 1026-30
被引量:88
摘要
The entry and differentiation of lymphoid precursor cells (LPC) in grafted mouse fetal thymuses and the emigration of explants thymocytes has been followed in a system in which donor and host lymphocytes could be distinguished on the basis of Thy-1 expression. It appears that LPC that invade the fetal mouse thymus between 10 and 13 days rapidly differentiate into Thy-1 positive thymocytes, giving rise to all of the lymphoid populations of both cortical and medullary locations until approximately the end of the first week after birth. Lymphoid precursor cells that enter the fetal thymus after 13 days of fetal life only differentiate into Thy-1 positive lymphocytes 6 or 7 days after birth, when they give rise to a second generation of thymocytes that grows exponentially and completely replaces the first generation in approximately 8 days. All cells leaving the thymus during the first 2 wk of life appear to be derived from the first wave of precursors.
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