结直肠癌
蛋白质组学
转化研究
医学
癌症
翻译后修饰
癌症研究
计算生物学
生物信息学
肿瘤科
内科学
生物
病理
生物化学
基因
酶
作者
Bruno Augusto Alves Martins,Gabriel Fonseca de Bulhões,Igor Norat Cavalcanti,Mickaella Michelson Martins,Paulo Gonçalves de Oliveira,Aline Maria Araújo Martins
标识
DOI:10.3389/fonc.2019.01284
摘要
Colorectal cancer is one of the most common cancers in the world, and it is one of the leading causes of cancer-related death. Despite recent progress in the development of screening programs and in the management of patients with colorectal cancer, there are still many gaps to fill, ranging from the prevention and early diagnosis to the determination of prognosis factors and treatment of metastatic disease, to establish a personalized approach. The genetic profile approach has been increasingly used in the decision-making process, especially in the choice of targeted therapies and in the prediction of drug response, but there are still few validated biomarkers of colorectal cancer for clinical practice. The discovery of non-invasive, sensitive, and specific biomarkers is an urgent need, and translational proteomics play a key role in this process, as they enable better comprehension of colorectal carcinogenesis, identification of potential markers, and subsequent validation. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through proteomics studies according to biomarker function and clinical application.
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