第一季
高强度间歇训练
MFN1型
MFN2型
线粒体生物发生
认知功能衰退
间歇训练
内科学
内分泌学
超氧化物歧化酶
氧化应激
医学
线粒体融合
心理学
生物
线粒体
细胞生物学
痴呆
疾病
线粒体DNA
生物化学
基因
作者
Baixia Li,Fei Liang,Xiaoyan Ding,Yan Qu,Yongcai Zhao,Xianliang Zhang,Yidong Bai,Tao Huang,Bo Xu
标识
DOI:10.1016/j.bbr.2019.112171
摘要
Exercise is a non-pharmacological strategy that may help to protect against cognitive decline and reduce the risk of Alzheimer’s disease. However, the optimal exercise modes for cognitive benefits are controversial. Mitochondrial function has been related to both exercise and cognition. The present study aimed to investigate the effects of two exercise modes on cognitive function and mitochondrial dynamics in APP/PS1 transgenic mice. The results showed that 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) could improve exploratory behavior, spatial learning and memory ability of APP/PS1 transgenic mice. Both HIIT and MICT interventions significantly alleviated the hippocampal β-Amyloid (Aβ) burden and mitochondrial fragmentation and improved mitochondrial morphology in hippocampus. Furthermore, both HIIT and MICT interventions down-regulated dynamin-related protein 1 (DRP1) and fission 1 (FIS1), whereas mitofusin 1 (MFN1), mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) were up-regulated. Hippocampal levels of total reactive oxygen species (ROS), malondialdehyde (MDA) and hydrogen peroxide (H2O2) were decreased, whereas activities of superoxide dismutase (SOD) and catalase (CAT) were elevated by HIIT and MICT. The study suggests that both HIIT and MICT alleviate cognitive decline and down-regulat Aβ level in the hippocampus in APP/PS1 transgenic mice, which may be mediated by improvements in mitochondrial morphology and dynamics.
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