巨噬细胞
效应器
生物
炎症
细胞生物学
柠檬酸循环
重编程
功能(生物学)
先天免疫系统
代谢物
细胞内
新陈代谢
免疫系统
生物化学
免疫学
细胞
体外
作者
Wei He,Alexander Heinz,Dieter Jahn,Karsten Hiller
标识
DOI:10.1016/j.copbio.2021.01.020
摘要
Macrophages are the prominent innate immune cells to combat infection and then restore tissue homeostasis after clearance of pathogens. Intracellular metabolic reprogramming is required for macrophage activation and function, as such adaptations confer macrophages with sufficient energy and metabolites to support biosynthesis and diverse functions. During the last 10 years, knowledge in this field has been greatly extended by outstanding advances demonstrating that several metabolic intermediates possess the ability to directly control macrophage activation and effector functions by various mechanisms. Of note, citrate and succinate contribute to the inflammatory activation of macrophages while tricarboxylic acid cycle-derived metabolite itaconate has a variety of immunomodulatory effects. Such progress not only encourages a further exploration into the emerging new area immunometabolism, but also provides potential therapeutic targets to control unwanted inflammation due to infection.
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