硫氰酸铵
过氧化氢
化学
硫氰酸盐
水溶液
基质(水族馆)
铵
氨基酸
无机化学
有机化学
生物化学
海洋学
地质学
作者
Danish Ali,Anoop Kumar Panday,Lokman H. Choudhury
标识
DOI:10.1021/acs.joc.0c01738
摘要
A rapid metal- and additive-free room temperature method for C(sp2)-H thiocyanation of aminopyrazoles, aminoisoxazole, aminoisothiazole, amino uracils, and aliphatic enamines has been developed in an aqueous medium using hydrogen peroxide as a benign oxidant and ammonium thiocyanate as a thiocyanating agent. On the other hand, the reaction of hydrogen peroxide and ammonium thiocyanate followed by one-pot addition of NaOH provides the corresponding disulfides in the case of amino azoles, and pyrimidine-fused 2-amino thiazoles were observed in the case of aminouracils. The salient features of this method are the use of an eco-friendly oxidant, reaction tunability to access different products, wide substrate scope, and good to very good yields.
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