生物材料
脚手架
生物医学工程
材料科学
骨移植
再生(生物学)
组织工程
纳米技术
外科
医学
细胞生物学
生物
作者
Hideo Fushimi,Takahiro Hiratsuka,Ai Okamura,Yoshitaka Ono,Izumi Ogura,Ichiro Nishimura
标识
DOI:10.1038/s43246-020-00089-9
摘要
Abstract Autografts and allografts are currently considered the gold standard for grafting surgery; however, to meet the growing demand in fast-aging societies, synthetic biomaterials will play an increasingly important role. Here we report a biodegradable scaffold material composed of recombinant polypeptide based on the human type I collagen alpha 1 chain (RCPhC1) as a source of hydrogel-based graft materials. The flexibility to engineer ideal characteristics for bone grafts was demonstrated. The critical internal isotropic pore structure was generated through a designed thin-layer freeze casting process. The optimized biodegradation rate was controlled by dehydrothermal crosslinking by adjusting the amino acid composition of RCPhC1. As a result, RCPhC1 bone grafts manufactured by a highly scalable streamlined production protocol induced robust regeneration of mature bone tissue while being completely resorbed in pre-clinical animal models.
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