Progress on Induced Pluripotent Stem Cell

Induced pluripotent stem(iPS)-cell technology was a new developmental technology of molecular biology recently in 2-3 years,iPS-cell technology demonstrates that mouse somatic cells can be directly reprogrammed into pluripotent embryonic stem(ES) cell-like cells by in vitro introduction of four transcription factors,Oct4,Sox2,c-Myc and Klf4.These cells are named as induced pluripotent stem(iPS) cells.Similarly,the transfection with these four transcription factors or Oct4,Sox2,Nanog and LIN28 has been shown to be sufficient to reprogram human somatic cells to iPS cells.Further studies confirm that iPS cells have same basic characteristics with human ES cells.However,whether viral vector or introduction gene have risk,thereby clinic application prospect of iPS cells are limited greatly.To overcome risk of iPS cells,scientists by untiring effects study out production methods of iPS cells that mainly are used non-viral transfection vector,ordinary skin cells are transferred into induced pluripotent stem cell safely.Based upon the data from recent publications,iPS cells have widely application prospect in clinic medicine,regenerative medicine,drug screening,and establishment of disease models,so that scientists of biomedicine are good graces about it.