Research States of Biological Active Targeted Polymeric Drug Carriers

Many drugs that are administered in an unmodified form by conventional systemic routes fail to reach target organs in an effective concentration,or are not effective over a length of time due to a facile metabolism.Various types of targeted delivery systems and devices have been tried over a long period of time to overcome these problems.The progress of studies of biological active targeted polymeric drug carriers is summarized.This review focus on synthesis,cytotoxicity test and in vivo experiment of several types of polymeric drug carriers such as folate-targeted,biotin-targeted and other biological active targeted polymeric drug carriers.The results show that biological active targeted drug carriers can improve the bioavability of drug,and reduce the side effects of the drug.