GW24-e0407 Effect of rosuvastatin on renal function of patients with mild or moderate renal disfunction and type 2 diabetes undergoing cardiovascular angiographic

Objectives

To observe effect of rosuvastatin on renal function in patients with mild or moderate renal disfunction and type 2 diabetes undergoing cardiovascular angiographic.

Methods

This study included 84 patients with mild or moderate renal disfunction and type 2 diabetes undergoing cardiovascular angiographic in wuhan asian heart hospital. The patiens were were randomised into rosuvastatin groups and control groups. The change of glomerular filtration rate (GFR) in the second or third postoperative day compared to baseline level were observed, and the change of urine albumin creatinine ratio (a/c) in postoperative 3 days compared to baseline level were also observed.

Results

The change of glomerular filtration rate from baseline in postoperative 2 days (ml/min): rosuvastatin groups (-0.017 ± 0.109) vs control groups (0.043 ± 0.112), P = 0.018. The change of glomerular filtration rate from baseline in postoperative 3 days (ml/min):rosuvastatin groups (-0.045 ± 0.1) vs control groups (0.002 ± 0.035), P = 0.035. The change of urine albumin creatinine ratio (a / c) (ug / ml) from baseline in postoperative 3 days: rosuvastatin groups (0.164 ± 2.254) vs control groups (-0.450 ± 0.966), P = 0.147.

Conclusions

Rosuvastatin may be slightly lower GFR in the second or third postoperative day in patients with mild or moderate renal insufficiency with type 2 diabetes undergoing cardiac angiography, but does not affect the urinary albumin creatinine ratio (a/ c) in the third postoperative day.