Objective:To observe the therapeutic effect of narrow-band UVB combined with glycyrrhizin compound on chronic eczema. Methods:81 cases of patients with chronic eczema were randomly divided into treatment group 42 cases and the control group 39 cases . The treatment group was treated with narrow-band UVB therapy once every two days combined with compound glycyrrhizin capsules 150 mg,3 times a day;the control group was treated only with compound glycyrrhizin capsules 150 mg,3 times a day. Two groups were treated for 4 weeks altogether. Results:The efficacy rate of therapy group (95%)was obviously better than the control (64%). Conclusion:The narrow-band UVB combined with compound glycyrrhizin treatment is a safe and effective treatment for chronic eczema.