细胞内
线粒体
跨膜蛋白
膜电位
细胞生物学
化学
细胞器
生物化学
生物
受体
作者
Zholobak Nm,Nataliya Kavok,Bogorad-Kobelska Os,Borovoy Ia,Malyukina My,Spivak My
出处
期刊:Fìzìologìčnij žurnal
日期:2012-04-24
卷期号:58 (2): 39-43
被引量:3
摘要
The influence of tilorone dihydrochloride and its analogues--diphenyl derivatives on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been estimated. Authors have shown a significant increase in mitochondrial potential thirty minutes after the introduction of the test compounds to the cells using the fluorescent probe JC-1. These results indicate the rapid activation with tilorone and its analog--dihydrochloryde 4,4'-bis-[2-(diethylamino)ethoxy]diphenyl--of the RLR signaling pathway. The final stage of this pathway is the cell production of IFN type I. The authors concluded that there is an increasing of the organelles resistance to the extra/intracellular damaging agents under the influence of the test compounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI