化学
超分子化学
癌症
细胞毒性
纳米技术
癌症研究
癌症治疗
环糊精
光动力疗法
癌细胞
癌症治疗
组合化学
超分子组装
活力测定
活性氧
肺癌
结直肠癌
肿瘤微环境
细胞
肿瘤细胞
生物相容性材料
作者
Shuai Chen,Ning Han,Yuheng Ren,Hongxia Wang,Jianmei Yang,Junnan He,Mingming Chen,Fei Zhu,Jinxin Yang,Yan Zhao,Jin Zhang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2025-10-01
卷期号:26 (10): 7165-7176
被引量:1
标识
DOI:10.1021/acs.biomac.5c01597
摘要
Lung cancer remains the leading cause of cancer mortality, highlighting the need for innovative therapies. Aloe-emodin (AE), a natural anthraquinone from Aloe vera, faces clinical challenges due to tumor heterogeneity and immunosuppressive microenvironments. To address this, we combine chemodynamic therapy (CDT) with a novel supramolecular assembly (MIL-101(Fe)-Fc@AE@FACD), designed by functionalizing iron-based metal-organic frameworks (MIL-101(Fe)) with folic acid-conjugated cyclodextrin (FACD) for tumor targeting. This assembly enables dual therapeutic mechanisms: CDT-induced reactive oxygen species (ROS) generation and pH-triggered AE release. In vitro, it shows enhanced cytotoxicity against A549 cells, reducing cell viability to <15%. In vivo, it significantly inhibits tumor growth with minimal hepatorenal toxicity. This hybrid supramolecular platform enhances the antitumor efficacy of AE against lung cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI