针灸科                        
                
                                
                        
                            再生医学                        
                
                                
                        
                            计算机科学                        
                
                                
                        
                            纳米技术                        
                
                                
                        
                            医学                        
                
                                
                        
                            替代医学                        
                
                                
                        
                            材料科学                        
                
                                
                        
                            病理                        
                
                                
                        
                            干细胞                        
                
                                
                        
                            遗传学                        
                
                                
                        
                            生物                        
                
                        
                    
            作者
            
                Ruisi Cai,Chenyi Yu,Xinyi Luo,Na Xu,Jicheng Yu,Xiao Ye,Yuqi Zhang,Zhen Gu            
         
                    
        
    
            
            标识
            
                                    DOI:10.1002/advs.202505318
                                    
                                
                                 
         
        
                
            摘要
            
            Abstract Acupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin‐neuro‐immune axis and inflammation‐immune modulation. However, traditional acupuncture faces several limitations, such as its complex operation, the wide variety of acupoint combinations, long treatment durations, and susceptibility to individual differences between the practitioner and the patient. These challenges highlight the urgent need for intelligent medical devices that enable more precise and efficient modern acupuncture treatment. In response to this, this manuscript introduces engineered acupuncture needles (EANs) using techniques such as macroscopic mechanical etching, microscopic surface modification, and biomedical nanotechnology. These modified needles enhance acupuncture treatment by incorporating drug delivery, electrical stimulation, and thermal stimulation technologies. Here we provide an overview of recent advancements in EANs in terms of materials, fabrication methods, engineering technologies, acupoints, as well as disease models. The relevant bottlenecks and future prospects of their development are also discussed.
         
            
 
                 
                
                    
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