Construction of β-Oximino Phosphorodithioates via (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl-Promoted Difunctionalization of Alkenes with tert-Butyl Nitrite, P4S10, and Alcohols
化学
亚硝酸盐
有机化学
药物化学
硝酸盐
作者
Xiaoming Chen,Jianguo Huang,Jun Pan,Yun Xie,Fei Zeng,Wei Wei,Dong Yi
出处
期刊:Organic Letters [American Chemical Society] 日期:2024-04-29
A (2,2,6,6-tetramethylpiperidin-1-yl)oxyl-mediated difunctionalization of alkenes with tert-butyl nitrite, P4S10, and alcohols has been developed for the synthesis of β-oximino phosphorodithioates. The reaction goes through a radical pathway with the successive installation of phosphorodithioate and an oxime group. This four-component protocol offers a practical approach to constructing a variety of β-oximino phosphorodithioates in moderate to good yields with favorable functional group tolerance.