PI3K/AKT/mTOR通路
蛋白激酶B
基因敲除
髓系白血病
癌症研究
细胞生长
柔红霉素
细胞凋亡
生物
化学
白血病
信号转导
分子生物学
细胞生物学
免疫学
生物化学
遗传学
作者
Xiaoyan Zhang,Lin Yang,Xiaojun Liu,Zi-Yuan Nie,Meng‐Han Liu,Tianyang Wang,Yaqiong Lu,Yuxia Pan,Ying Zhan,Zhenzhen Wang,Jianmin Luo
标识
DOI:10.1016/j.bbamcr.2023.119607
摘要
Acute myeloid leukemia (AML) presents ongoing therapeutic challenges due to its intricate molecular pathogenesis. This study aimed to elucidate the role of RNA binding motif protein 39 (RBM39) in AML cell proliferation, apoptosis, and chemosensitivity, and its potential modulation of the PI3K/AKT pathway.
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