化学
催化作用
组合化学
基质(水族馆)
产量(工程)
复分解
有机合成
光催化
化学合成
有机化学
体外
生物化学
海洋学
材料科学
地质学
聚合物
冶金
聚合
作者
Zhiqiang Zhu,Shaoshuai Chen,Dian Qiu,B Li
标识
DOI:10.1002/ejoc.202300534
摘要
Abstract An efficient and straightforward methodology for the synthesis of 1,2,2‐triarylethanones and 2,2‐diarylethanones has been developed, via a visible light‐promoted/Brønsted acid‐catalyzed carbonyl‐alkyne metathesis/transfer hydrogenation one‐pot reaction of benzoquinone, arylalkyne, and Hantzsch ester. A series of synthetically useful triarylethanones and diarylethanones were achieved in excellent yield under mild reaction conditions. This protocol is operationally simple, photocatalyst‐free, and scalable and has a broad substrate scope. Moreover, this reaction involves the formation of three chemical bonds, namely C=O, C−C, and C−H bonds. This feature enables de novo synthesis of 1,2,2‐triarylethanones and 2,2‐diarylethanones. Additionally, this protocol provides a convenient and practical synthetic route for tamoxifen.
科研通智能强力驱动
Strongly Powered by AbleSci AI