间充质干细胞
发病机制
生物
细胞生物学
微泡
细胞外
干细胞
细胞外小泡
小泡
免疫学
生物化学
小RNA
膜
基因
作者
Byoung-Chul Yang,Ya‐Qiu Long,Anyuan Zhang,Hongxiang Wang,Zhichao Chen,Qiubai Li
出处
期刊:Stem Cells
[Wiley]
日期:2023-11-15
卷期号:42 (2): 98-106
标识
DOI:10.1093/stmcls/sxad087
摘要
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell types and secrete extracellular vesicles (EVs) that transport bioactive molecules and mediate intercellular communication. MSCs and MSC-derived EVs (MSC-EVs) have shown promising therapeutic effects in several diseases. However, their procoagulant activity and thrombogenic risk may limit their clinical safety. In this review, we summarize current knowledge on procoagulant molecules expressed on the surface of MSCs and MSC-EVs, such as tissue factor and phosphatidylserine. Moreover, we discuss how these molecules interact with the coagulation system and contribute to thrombus formation through different mechanisms. Additionally, various confounding factors, such as cell dose, tissue source, passage number, and culture conditions of MSCs and subpopulations of MSC-EVs, affect the expression of procoagulant molecules and procoagulant activity of MSCs and MSC-EVs. Therefore, herein, we summarize several strategies to reduce the surface procoagulant activity of MSCs and MSC-EVs, thereby aiming to improve their safety profile for clinical use.
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