促炎细胞因子
嗅觉缺失
医学
肌痛
趋化因子
病理生理学
免疫学
喉咙痛
病例对照研究
疾病严重程度
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
疾病
2019年冠状病毒病(COVID-19)
内科学
炎症
传染病(医学专业)
作者
Rafhaella N D G Gondim,Érico Antônio Gomes de Arruda,Roberto da Justa Pires Neto,Melissa Soares Medeiros,José Q. Filho,Marco Clementino,Lyvia Maria Vasconcelos Carneiro Magalhães,Karene Ferreira Cavalcante,Vânia Angelica Feitosa Viana,Liana Perdigão Mello,Luciana M. B. Carlos,Alexandre Havt,Aldo A. M. Lima
摘要
Several biomarkers have been evaluated as predictors of severity or in directing the treatment of COVID-19, however there are no conclusive results. In this study, we evaluated serum levels of cytokines, chemokines, and cell growth factors in association with the pathobiology of mild to moderate SARS-CoV-2 infection. Serum levels of SARS-CoV-2 infected patients (n = 113) and flu symptoms individuals negative for SARS-CoV-2 (n = 58), tested by the RT-qPCR test-nasal swab were compared to healthy controls (n = 53). Results showed that the proinflammatory cytokines IL-1β, MCP-3, TNF-α, and G-CSF were increased in symptomatic patients and the cytokines IL-6 and IL-10 were associated with patients positive for SARS-CoV-2 when compared to healthy controls. Symptoms associated with COVID-19 were fever, anosmia, ageusia, and myalgia. For patients without SARS-CoV-2 infection, their major symptom was sore throat. The pathobiology of mild to moderate SARS-CoV-2 infection was associated with increasing proinflammatory cytokines and a pleiotropic IL-6 and anti-inflammatory IL-10 cytokines compared to healthy controls. Thus, knowledge about the pathophysiology and the involvement of biomarkers in the mild to moderate profile of the disease should be evaluated. Monitoring these biomarkers in patients with mild to moderate disease can help establish adequate treatment and prevention strategies for long-term COVID-19.
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