Engineering and Development of a Tissue Model for the Evaluation of Microneedle Penetration Ability, Drug Diffusion, Photothermal Activity, and Ultrasound Imaging: A Promising Surrogate to Ex Vivo and In Vivo Tissues (Adv. Mater. 18/2023)

Advanced MaterialsVolume 35, Issue 18 2370127 FrontispieceFree Access Engineering and Development of a Tissue Model for the Evaluation of Microneedle Penetration Ability, Drug Diffusion, Photothermal Activity, and Ultrasound Imaging: A Promising Surrogate to Ex Vivo and In Vivo Tissues (Adv. Mater. 18/2023) Pooyan Makvandi, Pooyan Makvandi Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, Italy School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh, EH9 3JL UKSearch for more papers by this authorMajid Shabani, Majid Shabani The BioRobotics Institute, Scuola Superiore Sant'Anna, Pontedera, 56025 Pisa, Italy Bioinspired Soft Robotics Laboratory, Istituto Italiano di Tecnologia, 16163 Genova, ItalySearch for more papers by this authorNavid Rabiee, Navid Rabiee Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150 Australia School of Engineering, Macquarie University, Sydney, New South Wales, 2109 AustraliaSearch for more papers by this authorQonita Kurnia Anjani, Qonita Kurnia Anjani School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL UKSearch for more papers by this authorAziz Maleki, Aziz Maleki Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139–56184 IranSearch for more papers by this authorEhsan Nazarzadeh Zare, Ehsan Nazarzadeh Zare School of Chemistry, Damghan University, Damghan, 36716–45667 IranSearch for more papers by this authorAkmal Hidayat Bin Sabri, Akmal Hidayat Bin Sabri School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL UKSearch for more papers by this authorDaniele De Pasquale, Daniele De Pasquale Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, ItalySearch for more papers by this authorMaria Koskinopoulou, Maria Koskinopoulou Department of Advanced Robotics (ADVR), Istituto Italiano di Tecnologia, 16163 Genova, ItalySearch for more papers by this authorEsmaeel Sharifi, Esmaeel Sharifi Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, 65178-38736 IranSearch for more papers by this authorRossella Sartorius, Rossella Sartorius Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 80131 Naples, ItalySearch for more papers by this authorMohammad Seyedhamzeh, Mohammad Seyedhamzeh Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139–56184 IranSearch for more papers by this authorShayesteh Bochani, Shayesteh Bochani Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139–56184 IranSearch for more papers by this authorIkue Hirata, Ikue Hirata Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, ItalySearch for more papers by this authorAna Cláudia Paiva-Santos, Ana Cláudia Paiva-Santos Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, Coimbra, 3000–548 Portugal LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, Coimbra, 3000–548 PortugalSearch for more papers by this authorLeonardo S. Mattos, Leonardo S. Mattos Department of Advanced Robotics (ADVR), Istituto Italiano di Tecnologia, 16163 Genova, ItalySearch for more papers by this authorRyan F. Donnelly, Ryan F. Donnelly School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL UKSearch for more papers by this authorVirgilio Mattoli, Virgilio Mattoli Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, ItalySearch for more papers by this author Pooyan Makvandi, Pooyan Makvandi Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, Italy School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh, EH9 3JL UKSearch for more papers by this authorMajid Shabani, Majid Shabani The BioRobotics Institute, Scuola Superiore Sant'Anna, Pontedera, 56025 Pisa, Italy Bioinspired Soft Robotics Laboratory, Istituto Italiano di Tecnologia, 16163 Genova, ItalySearch for more papers by this authorNavid Rabiee, Navid Rabiee Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA 6150 Australia School of Engineering, Macquarie University, Sydney, New South Wales, 2109 AustraliaSearch for more papers by this authorQonita Kurnia Anjani, Qonita Kurnia Anjani School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL UKSearch for more papers by this authorAziz Maleki, Aziz Maleki Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139–56184 IranSearch for more papers by this authorEhsan Nazarzadeh Zare, Ehsan Nazarzadeh Zare School of Chemistry, Damghan University, Damghan, 36716–45667 IranSearch for more papers by this authorAkmal Hidayat Bin Sabri, Akmal Hidayat Bin Sabri School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL UKSearch for more papers by this authorDaniele De Pasquale, Daniele De Pasquale Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, ItalySearch for more papers by this authorMaria Koskinopoulou, Maria Koskinopoulou Department of Advanced Robotics (ADVR), Istituto Italiano di Tecnologia, 16163 Genova, ItalySearch for more papers by this authorEsmaeel Sharifi, Esmaeel Sharifi Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, 65178-38736 IranSearch for more papers by this authorRossella Sartorius, Rossella Sartorius Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 80131 Naples, ItalySearch for more papers by this authorMohammad Seyedhamzeh, Mohammad Seyedhamzeh Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139–56184 IranSearch for more papers by this authorShayesteh Bochani, Shayesteh Bochani Zanjan Pharmaceutical, Nanotechnology Research Center (ZPNRC), Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, 45139–56184 IranSearch for more papers by this authorIkue Hirata, Ikue Hirata Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, ItalySearch for more papers by this authorAna Cláudia Paiva-Santos, Ana Cláudia Paiva-Santos Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, Coimbra, 3000–548 Portugal LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, Coimbra, 3000–548 PortugalSearch for more papers by this authorLeonardo S. Mattos, Leonardo S. Mattos Department of Advanced Robotics (ADVR), Istituto Italiano di Tecnologia, 16163 Genova, ItalySearch for more papers by this authorRyan F. Donnelly, Ryan F. Donnelly School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL UKSearch for more papers by this authorVirgilio Mattoli, Virgilio Mattoli Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, Pontedera, 56025 Pisa, ItalySearch for more papers by this author First published: 04 May 2023 https://doi.org/10.1002/adma.202370127AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Tissue Models In article number 2210034, Pooyan Makvandi, Virgilio Mattoli, and co-workers report the fabrication of tissue substitutes for ex vivo human tissues and animals. Tissue models based on hydrogel/silicon films are prepared for different applications in the biomedical sector. These customized tissue surrogates can be employed as a platform to evaluate the ability of microneedle insertion, diffusion of drugs, activity of photothermal agents, and the performance of ultrasound bioimaging. Volume35, Issue18May 4, 20232370127 RelatedInformation