化学
质谱成像
药品
代谢途径
质谱法
代谢组学
药物代谢
计算生物学
生物转化
分子成像
药理学
新陈代谢
生物化学
酶
体内
色谱法
医学
生物
生物技术
作者
Xiaowei Song,Qingce Zang,Jin Zhang,Shanshan Gao,Kailu Zheng,Yan Li,Zeper Abliz,Jiuming He
标识
DOI:10.1021/acs.analchem.2c01723
摘要
Metabolic perturbation score-based mass spectrometry imaging (MPS-MSI) is proposed to reveal the spatially resolved functional metabolic response associated with disease progression or drug action including metabolism pathways, species, biofunction, or biotransformation. The MPS-MSI enables the exploration of therapeutic or adverse effects, regional heterogeneous responses to drug treatment, possible molecular mechanisms, and even drug potential targets. MPS-MSI was demonstrated to be a promising molecular imaging tool not only for efficacy and safety evaluation but also for molecular mechanism investigation at the early stage of drug research and development.
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