自噬
卵母细胞
细胞生物学
生物
细胞内
PI3K/AKT/mTOR通路
信号转导
生物化学
细胞凋亡
胚胎
出处
期刊:Cell Cycle
[Informa]
日期:2023-02-14
卷期号:22 (9): 1074-1076
标识
DOI:10.1080/15384101.2023.2176673
摘要
Selective autophagy specifically eliminates certain intracellular substrates through the autophagy pathway. Organelles and aggregation-prone proteins can be degraded through the autophagy receptor protein SQSTM1/p62, which renders them a promising therapeutic approach against infertility. He et al. demonstrate that blocking of autophagy in cumulus granulosa cells can directly attenuate citrate levels and in turn affect oocyte maturation quality. Further findings show that SQSTM1 connects K63-polyubiquitinated ACLY (ATP citrate lyase) during the process of selective autophagic degradation, which further compromises the homeostasis of citrate. Therefore, the quality of oocyte meiotic maturation can be evaluated by the levels of selective autophagy in cumulus granulosa cells.
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