归巢(生物学)
生物
淋巴细胞归巢受体
免疫学
免疫系统
受体
免疫球蛋白D
记忆B细胞
B细胞
幼稚B细胞
细胞生物学
T细胞
细胞
细胞粘附
抗原提呈细胞
抗体
遗传学
生态学
作者
Lusijah S. Rott,Michael Briskin,Eugene C. Butcher
摘要
Abstract We have examined the expression of homing receptors on circulating memory B cells subsets. Blood IgD+ (naive) B cells homogeneously express a high level of intestinal homing receptor, α4β7, but IgD− (putative memory) B cells comprise distinct α4β7+ and α4β7− subsets. Naive and α4β7+ memory B cells but not α4β7− cells bind MAdCAM-1, suggesting that α4β7 expression may predict B cell intestinal homing. In contrast, α4β7+ and α4β7− B cells bind well to VCAM-1, possibly allowing recruitment of both subsets to extra-intestinal sites, including those tissues of the “common mucosal immune system” characterized by vascular VCAM-1 expression. sIgA+ B cells, which are associated with mucosal immunity in the gut and elsewhere, are heterogeneous in homing receptor expression—with discrete subsets expressing α4β7, L-selectin, and cutaneous lymphocyte antigen (CLA). sIgA+ CLA+ B cells are enriched by binding to E-selectin, suggesting that CLA may participate in B cell homing to nonintestinal mucosal tissues characterized by vascular E-selectin expression, such as chronically inflamed bronchial or oral mucosal. We conclude that circulating human peripheral blood memory B cells, like T cells, consist of discrete homing receptor-defined subsets. This diversity in homing phenotypes is apparent even among sIgA (presumptive mucosal) memory B cells, implying heterogeneity in trafficking mechanisms to different target mucosal surfaces.
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