Novel Wet-Field Mineral-Organic Adhesives Used to Repair and Regenerate Bone

We describe the development and properties of a novel class of biomimetic and bioactive, mineral-organic, injectable, wet-field, high-strength bone adhesives providing new capabilities for surgeons. Tetranite has immediate load-bearing strength, durably bonding living bone and metal surfaces. Handling properties and biodegradation kinetics are widely tunable through multiple paths of formulation design. These calcium phosphate-based adhesives are bioactive, biodegradable, osteoconductive, and remarkably bone regenerative. The O-phospho-L-serine constituent, a common endogenous metabolite, has been shown to promote regenerative biological response, stimulating proliferation and phenotypic expression of osteoblasts. This unique bio-adhesive class is currently undergoing clinical trials in orthopedic and dental fields. The user-friendly properties are expected to improve clinical practice and patient outcomes by allowing new minimally invasive approaches, improved recovery times, reduced pain, and lowered cost of care.