环加成
表面改性
废止
分子内力
串联
化学
催化作用
组合化学
背景(考古学)
甲亚胺叶立德
1,3-偶极环加成
有机化学
材料科学
古生物学
物理化学
复合材料
生物
作者
Neeraj Kumar Mishra,Amitava Rakshit,Kyeongwon Moon,Pardeep Singh,In Su Kim
摘要
Abstract The synthesis and functionalization of privileged nitrogen heterocycles has emerged as a central topic in drug discovery and material science. In this context, the tandem C–H functionalization and intramolecular annulation has received prodigious attention, as it is able to expedite the construction of heteroaromatic frameworks beyond conventional C–H functionalization. In general, significant effort has been made to develop the [3 + 2] dipolar cycloaddition of azomethine imines with π‐unsaturated compounds. Moreover, the [3 + 3], [4 + 3], [3 + 2 + 2], and [5 + 3] cycloaddition reactions of azomethine imines with various dipolarophiles have been demonstrated. To date, however, the combination of catalytic C–H functionalization and intramolecular cyclization using azomethine imines as both directing groups and dipolar units has been less explored. This review focuses on recent progress toward the catalytic tandem C–H functionalization and dipolar cycloaddition of azomethines imines with a range of coupling partners.
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