光动力疗法
紧身衣
光化学
化学
光敏剂
癌症治疗
癌症
Atom(片上系统)
荧光
癌症研究
医学
有机化学
内科学
物理
计算机科学
光学
嵌入式系统
作者
Soumyaditya Mula,Mrunesh Koli
标识
DOI:10.1002/cmdc.202400041
摘要
Despite of having many advantages over the popular cancer therapies, photodynamic therapy still is not widely acceptable for clinical applications. Scarcity of efficient triplet photosensitizers (PSs) is one of the main bottlenecks for this. Although numerous heavy atom attached PSs are developed, but these are not suitable for clinical applications. Thus, development of heavy‐atom‐free organic PSs is urgently required. Here, development of new type of helical BODIPYs as PSs for PDT is discussed. BODIPYs have rich photophysical properties and structural helicity further enhances their triplet conversion rates. This new concept of structural helicity to enhance the triplet conversion of BODIPYs is discussed with reported helical BODIPYs. Helical geometries of these dyes are checked by X‐ray crystallography studies and their high triplet conversions are also confirmed. Importantly, these dyes have high triplet lifetimes and are capable of generating high singlet oxygens even in hypoxia condition as compared to conventional heavy atom attached BODIPYs. All these make the helical BODIPYs excellent candidates as PDT agents. Finally, their successful applications as PDT agents in killing of various types of cancer cells are also discussed. The results are encouraging which indicate that helical BODIPYs could be next generation heavy‐atom‐free PSs for PDT applications.
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