Disaccharide compositional analysis of chondroitin sulphate using WAX HILIC-MS with pre-column procainamide labelling; application to the placenta in pre-eclampsia

The disaccharide composition of placental chondroitin sulphate was analysed following pre-column labelling. This revealed changes in chondroitin sulphate in various pregnancy conditions and showed increased sulphation is related to maternal labour.